A new type of drug for one of the most common kinds of advanced breast cancer is now available on the NHS in England.

Some 3,000 women a year could benefit from capivasertib after a clinical trial showed it can slow progression of the disease, and shrink tumours in a quarter of people.

The drug has been given the green light for NHS funding by England's drug assessment body.

It's one of a range of treatment options available to people whose cancer has spread and is no longer curable, but a cancer charity said breast cancer drugs should be approved more quickly.

Breast cancer is the most common cancer in the UK, with one in seven women affected in their lifetimes and 75% surviving for 10 years or more after diagnosis.

If the cancer returns and spreads to other parts of the body, treatments aim to control it, reduce the symptoms and improve quality of life.

Possible treatments include chemotherapy, radiotherapy and drugs that help to stop the cancer growing - either by blocking hormones, boosting the body's immune system or targeting what makes cancer cells grow.

This new drug capivasertib is a targeted therapy. It works in a new way, blocking the activity of a protein molecule called AKT which drives cancer growth.

Scientists started working on the drug's development 20 years ago and say it's the most effective cancer drug they've seen for advanced cancer.

"It presents a very effective option that can work for a long time - many months, and in some people it can be years," said Prof Nick Turner, lead researcher and professor of medical oncology at the Institute of Cancer Research and The Royal Marsden.

In trials, in 708 women, when combined with hormone therapy, the drug doubled the time the cancer took to grow, from 3.6 months to 7.3 months. It also shrank tumours in 23% of patients.

"It can substantially delay chemotherapy which many women fear because of the side-effects," Prof Turner added.

"Advanced breast cancer is highly treatable and we want kinder, better treatments."

'Four years of extra time'

Linda Kelly, 67, is a keen gardener who keeps active by cycling 60 miles a week. She also does pilates.

Breast cancer has spread to her bones and chest wall.

But she's had "fantastic" results from the new drug capivasertib.

"It does let you have a normal kind of life and you forget you have cancer," she said.

"You feel the drug is working and you can be a lot calmer - it's given me nearly four years of extra time."

Linda and her husband are now planning to travel. She says the drug has given her hope.

"It does make you think about your life, and what you want to do with your life in the future - but at least you feel well enough to make those plans and confident enough as well to fulfil some of those plans."

The drug is suitable for those with certain gene mutations that affect up to half of people with hormone receptor positive secondary breast cancer - the most common type, which grows in the presence of oestrogen.

Professor Peter Johnson, clinical director for cancer at NHS England, said it offered "an additional option" for some whose cancer has progressed despite previous hormone therapy - but it wouldn't be suitable for everyone.

Claire Rowney, chief executive at charity Breast Cancer Now, said she was "delighted" that the drug would offer some people "the hope of more precious time to do what matters most to them".

But she said patients had "faced unnecessary delays in accessing it" after the drug was initially rejected by NICE, and breast cancer drugs should be approved more quickly for those who need them.

"NHS England must now put in place prompt genetic testing to ensure those eligible receive capivasertib without further delay," she said, adding that Scotland should also consider funding the treatment quickly so that patients across the UK would have access.

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The commander of the US military base in Greenland has been fired after she reportedly sent an email distancing herself from Vice-President JD Vance's criticism of Denmark.

The US military's Space Operations Command said Colonel Susannah Meyers had been removed from her duties at Pituffik Space Base due to a "loss of confidence in her ability to lead".

Last month, Vance used a trip to the Arctic island to criticise Denmark - of which Greenland is a territory - for not spending more on security in the region, claiming it had "not done a good job" for Greenlanders.

The alleged email, released by a US military news site, told personnel that Vance's comments were "not reflective" of the base.

Following the trip, on 31 March, Col Meyers is reported to have written: "I do not presume to understand current politics, but what I do know is the concerns of the US administration discussed by Vice-President Vance on Friday are not reflective of Pituffik Space Base."

Military.com - which published the email - said the contents had been confirmed as accurate to them by the US Space Force.

Appearing to confirm this was the reason for her firing, chief Pentagon spokesperson Sean Parnell linked to the Military.com article in a post on X, writing: "Actions [that] undermine the chain of command or to subvert President [Donald] Trump's agenda will not be tolerated at the Department of Defense."

The Space Force's statement announcing Col Meyers' removal on Thursday said that Col Shawn Lee was replacing her.

It added: "Commanders are expected to adhere to the highest standards of conduct, especially as it relates to remaining nonpartisan in the performance of their duties."

During his whirlwind trip, Vance had also reiterated Trump's desire to annex Greenland for security reasons.

Since the US delegation's visit, both Greenland and Denmark have shown a united front, opposing a US annexation of the autonomous Danish territory.

Earlier this month, Danish Prime Minister Mette Frederiksen's official visit saw her stand side-by-side with her Greenlandic counterpart Jens-Frederik Nielsen and his predecessor, Mute Egede.

Speaking to reporters, Frederiksen directly addressed Trump, telling him: "You can't annex other countries."

She added that Denmark was fortifying its military presence in the Arctic, and offered closer collaboration with the US in defending the region.

Greenland, the world's largest island, has been under Danish control for around 300 years.

Polls show that the vast majority of Greenlanders want to gain independence from Denmark - but do not wish to become part of the US.

Greenland has had the right to call an independence referendum since 2009, though in recent years some political parties have begun pushing harder for one to take place.

Organised crime gangs are behind a sharp rise in scams linked to fraudulent QR codes, experts say.

The national fraud reporting centre Action Fraud received 1,386 reports of people being targeted last year, compared with 100 in 2019.

Contactless payment hotspots - like parking meters and restaurant menus - are common targets of criminals who stick their own QR codes on signage.

Katherine Hart, lead officer at the Chartered Trading Standards Institute, said: "We've seen huge amounts lost this way. People have seen their life savings gone and that money is going to finance criminals."

She said quishing was significantly under-reported and presented a "huge challenge" to authorities globally.

'Hierarchy of criminals'

Fraudulent and misleading codes have also been spotted on parcels, in emails and on television.

People who scan them using mobile phones and other electronic devices are directed to websites controlled by the scammers and tricked into handing over data such as bank details.

Ms Hart said some of those placing the codes were likely to be at the bottom of a hierarchy of organised criminals and may not be aware of the implications of their actions.

Action Fraud statistics obtained by the BBC's Shared Data Unit suggest a rapid growth in this kind of scam, with recorded incidents more than doubling in the UK between 2023 and 2024.

Over the past five years, Action Fraud received almost 3,000 reports in total, with a fifth of those linked to the Metropolitan Police force area.

Milton Haworth used his mobile phone to scan a QR code at a council-run car park in Castleford, West Yorkshire.

It directed him to download an unauthorised app, from which he agreed a 90p fee to verify bank details.

But instead of paying to park, he found himself signed up to a subscription service with a £39 yearly fee and no refunds offered.

"I'd assumed I'd paid for my parking but realised it was a scam when I noticed the next day that £39 had gone out of my account," he said.

"The sign said to use the code to park and I hadn't ever heard of QR codes being used as a scam."

Mr Haworth blames the spike in cases on authorities "not taking this seriously enough".

He said: "Nobody seems to care, there doesn't seem to be anyone trying to find these people.

"It's incumbent on the authorities to go after them but I don't think they do because it's small amounts taken, not multimillions.

"But if it's £39 a month, what if there's a million people being duped?"

'Stay vigilant'

Ms Hart said victims often lost small amounts initially as those responsible gathered the data they needed to launch a "secondary scam".

"You might lose £2.99 and a lot of people won't report that and don't realise they've passed on their information to a criminal organisation," Ms Hart said.

"Days or weeks later, they get a call telling them they've been the victim of a fraud and they can pinpoint a day, because they already have all of the information you shared with them earlier.

"They convince you using very coercive tactics that they're from your bank, police or Trading Standards and they want to take everything you've got."

Experts including the National Crime Agency and the National Cyber Security Centre say it is vital that people "stay vigilant to cyber criminals".

Kirsty Blackman, Scottish National Party MP for Aberdeen North, spoke to the BBC after removing fake QR codes from parking machines in the city.

She said tackling the problem was "genuinely difficult", adding: "Organised criminals are there to make money in whatever way they can and I think they'll scam people whatever we do. It's about trying to whack the moles as they pop up."

She said the more victims filed reports with Action Fraud, the better police could take action.

"QR codes can be really useful," she said. "My kids' school sends them out regularly to share information, for example. That's why it's difficult for people to tell the difference between a legitimate code and a fake one.

"When you're scanning a code to pay for something, that's when you really need to stop and think."

Joe Hall's girlfriend inadvertently scanned a fraudulent QR code when trying to pay for parking in Luton before Christmas.

The couple now refuse to use QR codes after £400 was taken from her bank account the next day.

Mr Hall said: "I drove back to the car park and found the code she scanned was a sticker. They print them so everything's the same font and colours as the signage and it blends in.

"If you know what you're looking for, you might spot it but a lot of the time, you might not even think about it.

"It's so easy for them to make money out of it - there were four others behind my girlfriend doing the same thing as she did.

"She got her money back but that's not always the case. They could easily just empty your bank account."

'Rigorous checks'

National Car Parks, which runs 800 car parking sites across the UK, is considering removing QR codes from its signage.

It said a "rigorous process" had already been introduced to prevent its QR codes being compromised, with signs inspected and codes checked every day.

A spokesman said two of its car parks had been targeted by scammers and the business was "reviewing options" to reduce the impact of fraudulent QR codes.

He said: "This could include removing a QR code from our signage that directs customers to a payment page, and instead emphasising the use of our website.

"We understand the value of QR codes and will still look to use them where we can safely."

Det Supt Gary Miles, head of the National Fraud Intelligence Bureau, encouraged users to "stay alert" to signs of fraudulent codes.

"You should stop and check before scanning one," he said. "If you're in person, check for signs it has been tampered with, or online, look out for phishing emails or rogue social media posts with QR codes.

"We know that QR codes can be used in all aspects of life, online and in-person, however this doesn't stop fraudsters finding new ways to target members of the public."

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At 01:00 on Tuesday morning Carwin Javie Molleja was dancing with his mother in Santo Domingo's Jet Set nightclub when he noticed something fall from the ceiling.

At the time, he didn't think much of it. "No-one thought that because a small stone fell the entire roof was going to collapse," he says.

The percussionist, who had moved to the Dominican Republic eight years earlier, was out with his mother, Carmin, and friends to see a concert by merengue singer Rubby Pérez.

It was the first time Carwin, 32, and his mother had seen each other in three years and it was meant to be a night of joy and celebration.

But in the early hours of Tuesday morning, disaster struck.

"What I have in my head are the screams, the loud sound of the ceiling falling in, my mom's screams asking me if I'm OK, me asking her if she's OK," Carwin recalls.

"Everything happened so fast. I guess I closed my eyes and my instinct was to hug my mum."

Both Carwin and his mother, who had been standing near the stage, were struck on the head by pieces of falling ceiling, but were lucky to avoid serious injury. Rubby Perez was among those killed.

In the chaos that quickly unfolded, Carwin managed to find a door through which he and his mother escaped outside.

But his friend Jessica and her sister were still in the club. Desperate to find them, he decided to go back inside.

Inside the club, Carwin desperately shouted Jessica's name but no one answered.

He says he felt powerless to help those who had become trapped under the debris.

"The stones were huge. I felt useless."

Carwin says he then repeatedly went out of the building, where he'd try to call paramedics, then return inside to shout his friend's name and call her phone.

"After that, the calls stopped going through."

Carwin describes the aftermath of the collapse as "total chaos".

"People were going crazy," he says.

"They were pulling out injured people. I saw when they pulled out the saxophonist who died."

Within minutes of the collapse, emergency services arrived, as ambulances and stretchers "kept coming".

Carwin says he remained at the scene for about an hour and a half after the collapse.

In that time, he says he didn't see any machinery arriving to remove the debris.

He says he wanted to continue trying to find his friend, but needed to take home his mother, who was in pain.

"I needed to get her home and calm her down."

Later that day, Jessica and her sister's lifeless bodies were found among the rubble. At least 221 people were killed in the disaster.

Carwin says he regrets not having been able to do more for his friend.

"It was horrible not being able to help her. I yelled her name, but she didn't answer. It feels awful not being able to do anything."

With reporting by Isabel Caro and Alicia Hernández.

There were some heroic efforts overnight from Donald Trump and those around him to suggest the past seven days were something other than absolute chaos.

By this reading, Trump's 4D game of chess has left China in check. Certainly the Chinese economy faces a massive hit from punitive tariffs in its biggest market. But even accounting for the President's roll back, the US has still erected a massive protectionist tariff wall, not seen since the 1930s.

The world is left with a universal 10% tariff, irrespective of whether that country (for example the UK or Australia) actually sells less to the US than the US sells to it. There is now no difference between the EU, which clearly does have a massive trade deficit in goods and was preparing to retaliate, and the UK.

There is also an anxious wait to find out what comes next. One of the questions is whether President Trump pushes ahead with tariffs on medicines, the UK's second biggest goods export.

Plus there is potential logistical chaos on the cards from a little-noticed multi-million dollar port tax for every cargo vessel docking in the US that was "made in China". That is more than half of the global merchant fleet - and it is due next Friday.

Even with Trump's stated 90 day pause on implementing higher tariffs, there remains too much uncertainty for companies to go through the rigmarole of rerouting global trade.

The China fallout

The central issue today, however, is that the world's two great economic superpowers are now facing off against each other like rutting stags.

Tariffs at these sky-high rates are massively hitting business between two nations which together account for around 3% of the entire world's trade. The main motorway of the global economy is effectively shut.

The visible tangible consequences of all this will become very real very quickly: Chinese factories will close, workers will stroll from plant to plant looking for work.

Beijing will need to organise a stimulus package to account for the loss of whole percentage points of GDP, the kind of thing that happens when a natural disaster flattens a major city. Painful, but manageable at a cost, though not forever.

Meanwhile the US will see consumer prices surge. President Trump might try to order these US companies not to raise prices, but the effect will come through soon enough from the Amazon app to the iStore.

In theory this will be in sharp contrast to what is happening in other countries in the world. Across the border in Canada, or in Europe, not only will there not be such China-sourced price rises, there could be price cuts.

From trade wars to currency wars

Trade wars on this scale do not stay confined to the flow of goods. They tend to become currency wars.

What we saw last night was the trade turmoil spread to credit markets, especially the US bond market, having already hit share prices.

Indeed there was an invaluable reveal for the game theory of this conflict. The Trump administration revealed a key pressure point with its concern about the "yippy" - as Trump called it - bond market.

As trading in US government debt continued overnight in Asia, the effective interest rate on these bonds rose to 5%.

This sort of borrowing should not move in such an erratic fashion.

The last time this happened was in the "Dash for Cash", the key moment of financial fragility at the very beginning of the pandemic. The world was focussed on life or death in March 2020, but this potential further crisis was alleviated only by emergency action.

Effectively, the President's row back was a form of emergency policy change.

Was the Chinese government behind this rash of US government bond sales in Asia? Probably not. However, what happened on Wednesday highlighted a vulnerability for Trump.

China is the second biggest holder of US government debt in the world and if it chose to, dumping all that debt would be catastrophic for America. But doing so would be a form of mutually assured economic destruction - the losses for China would be huge.

More importantly, what the bond markets were telling Trump is that they are deeply sceptical about his tariff policy.

The US does have the Federal Reserve, which does have some power to tranquillise bond markets. But right now it does not look like its chairman Jerome Powell will ride to the rescue.

The bond market scepticism echoes the sentiment of the ascendant Treasury Secretary Scott Bessent. He is now pushing for Trump to reach trade deals with their allies because the US needs them to take on China.

Given the US was previously calling these same close allies cheaters, looters and pillagers, there is no way this was the strategy all along.

This does matter. The US needs the EU, UK, the rest of the G7 on side in terms of China. China probably needs those countries just to stay neutral, and carry on soaking up its exports.

The rest of the world has seen Trump's team struggle to explain tariffing penguin islands or poor African economies and the President himself recirculating the suggestion he was crashing stock markets on purpose. And they've witnessed the fact that the tariff rates were changed after they came into effect and also the absurd nature of the equation used to calculate them.

It's in this context that Trump's handling of the situation has handed leverage back to the rest of the world, because neither friend nor foe will negotiate with America while things are as they are.

There is a calm, welcomed by all, but it could be rather brief.

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A record shop owner who suffered a cardiac arrest after being stabbed with a syringe full of a powerful muscle relaxant says he fears he may never know why he was attacked.

Gary Lewis, 65, almost died when he was injected with rocuronium by 58-year-old nurse Darren Harris at Betterdaze in Northallerton on 2 July last year.

Harris, who is due to be sentenced later, was found guilty of attempted murder after a trial at Leeds Crown Court, but offered no explanation for the attack.

Speaking to the BBC, Mr Lewis said: "It leaves you with the quandary, sometimes bordering on paranoia, about why somebody would go to those lengths."

On the day of the attack Harris travelled from his home in Middlesbrough, where he worked as a nurse at James Cook Hospital, to Northallerton, where he stabbed Mr Lewis in the backside before leaving the shop.

Mr Lewis said he had followed Harris outside to confront him, but collapsed a short time later.

CCTV footage shows him leaving the shop to remonstrate with Harris, before neighbouring shopkeepers come to his assistance and police arrive to detain Harris.

"Apparently I died on the footpath, my heart stopped on the footpath," he said.

"I regained consciousness and they tell me I had a second cardiac arrest in the ambulance."

Mr Lewis said he had been told it was his decision to leave the shop, which he puts down to his training during 30 years in the police force, that saved his life.

"The doctors are absolutely certain," he said.

"If I'd stayed where I was I would have had the heart attack without anyone being around me and the next person to walk in the shop would have found me."

When Harris was arrested he repeatedly claimed the syringe had been full of water, but it was later found to have been filled with rocuronium.

Harris did not give evidence during his trial but in a police interview he claimed he had been pushed out of the shop by Mr Lewis following an argument.

CCTV footage showed no such altercation took place and no other motive for the attack has been put forward.

Mr Lewis said: "Nobody in the family can get their head around it. It's baffled the police, it's baffled the barristers, it's baffled the court, it's probably baffled the hospital.

"I'm not going to plead with the guy, but if he's got any humanity he will give me an explanation.

"It wasn't random, it couldn't have been more deliberate and targeted. Whether I'll ever find out, I almost have to deal with the possibility that I might not and that is psychologically impacting."

Mr Lewis said he was back at work within days of the attack, but said he had struggled with the idea that had he not made it out of the shop his heart attack might never have been revealed as attempted murder.

"The drug clears your system, which is why I would have died if I'd stayed in the shop," he said.

"It would have disappeared and nobody would have looked for a pin prick, it would have been put down as a cardiac arrest.

"But the psychology of it, there can't be many victims of such a crime who have to return to the scene of the crime every single day and sit in the same seat where you were attacked.

"I do not think it will ever be over and done with unless I am given a reason and I can't imagine what that reason would be.

"You rack your brains but you've almost got to not think about it too much because I may never get an explanation."

South Tees Hospitals NHS Foundation Trust said Harris' employment was terminated in August 2024.

It said a review into the storage of medications, including controlled drugs, in cardiac theatres and general theatres was carried out in light of the incident and concluded "all theatres were fully compliant with national guidance".

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