Taking Too Much Tylenol Has Proven Risks. Trump Didn’t Talk About Those. NYT | Top Stories Rebecca Robbins 7 October 2025 at 21:43 Acetaminophen’s link to autism is unproven. But hundreds of Americans accidentally overdose on the drug each year, suffering liver damage that can require a transplant or even be fatal. © Justin Sullivan/Getty ImagesExperts emphasize that Tylenol is safe when taken as directed, and the overall percentage of acetaminophen users who overdose is very small.